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Abatantuono was born in Milan to a father of Apulian origin and a mother from Como. The latter worked as wardrober in a Milanese jazz and later cabaret club, Derby, whose owner was Abatantuono's uncle. He started to work at Derby first in lighting, then as artistic director and later as an actor.
Diego Abatantuono is a prominent Italian cinema and theatre actor who began his career at the legendary Derby Club in Milan before transitioning to film.
He is best known for his roles in Academy Award-winning Mediterraneo, I'm Not Scared, and various Italian comedies such as Eccezzziunale... veramente.
He works primarily in Italian film and television, spanning broad comedy, character-driven dramas, and sci-fi projects.